Inflammatory Bowel Disease: Serologic Markers and Pharmacogenomic and Metabolic Assessment of Thiopurine Therapy
ثبت نشده
چکیده
I. Aetna considers TPMT gene mutation or TPMT phenotypic assays (e.g., Prometheus TPMT Genetics, Prometheus TPMT Enzyme) medically necessary prior to initiation of 6mercaptopurine or azathioprine therapy. Only 1 genotypic or phenotypic assay of TPMT activity is necessary per member per lifetime. TPMT gene mutation assays and TPMT phenotypic assays are considered experimental and investigational for all other indications because their effectiveness for indications other than the one listed above has not been established.
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Exome-Wide Pharmacogenomic Analysis of Response to Thiopurines in Inflammatory Bowel Disease Patients
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